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The Human Mitochondrial Genome: From Basic Biology to Disease – eBook

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eBook details

  • Authors: Giuseppe Gasparre, Anna Maria Porcelli
  • File Size: 25 MB
  • Format: PDF
  • Length: 596 pages
  • Publisher: Academic Press
  • Publication Date: July 23, 2020
  • Language: English
  • ASIN: B08DTKFC4S
  • ISBN-10: 0128196564, 0128226420
  • ISBN-13: 9780128196564, 9780128226421
SKU: the-human-mitochondrial-genome-from-basic-biology-to-disease-ebook Categories: , , , , Tags: , , , , , ,

Description

The Human Mitochondrial Genome: From Basic Biology to Disease – eBook PDF:

Author(s)

Anna Maria Porcelli

Giuseppe Gasparre

The Human Mitochondrial Genome: From Basic Biology to Disease – eBook

The Human Mitochondrial Genome: From Basic Biology to Disease, (PDF) provides a comprehensive, up-to-date examination of human mitochondrial genomics, linking basic research to translational medicine across a range of disease types.

Here, international specialists discuss the essential biology of human mitochondrial DNA (mtDNA), including its maintenance, repair, heredity and segregation. Moreover, mtDNA evolution and exploitation, mutations, models and methods for functional studies of mtDNA are dealt with.

Disease discussion is supplemented by approaches for treatment strategies, with disease areas discussed including cancer, age-related, mtDNA depletion, neurodegenerative, deletion, and point mutation diseases.

Nucleosides supplementation, mitoZNF and mitoTALENs nucleases are among the therapeutic approaches examined in-depth.

With growing funding for mtDNA studies, many clinicians scientists and clinician are turning their attention to mtDNA disease association.

This ebook provides the tools and background knowledge required to perform new, impactful research in this stimulating space, from distinguishing a haplogroup-defining variant or disease-related mutation to discovering emerging therapeutic pathways.

  • Outlines and discusses vital research protocols and perspectives for young scientists to pick up
  • Includes an international team of authoritative contributors from basic biologists to clinician-scientists
  • Disease discussion accompanied by diagnostic and therapeutic strategies presently implemented clinically
  • Completely examines recent advances and technological innovations in the field, enabling new mtDNA studies, variant and mutation identification, pathogenic assessment, and therapies

NOTE: The product only includes the ebook, The Human Mitochondrial Genome: From Basic Biology to Disease in PDF. No access codes are included.

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